Browse articles from EyeWorld.org related to crosslinking. EyeWorld is the award-winning member publication of ASCRS. The magazine provides news and updates from the Society as well as clinical features in the areas of cataract, refractive, cornea, glaucoma, and practice management. It publishes quarterly with editorial direction from its medical editorial board and staff.

U.S. physicians embrace epithelium-on crosslinking

U.S. ophthalmologists who have used the Epioxa system (Glaukos) for an epithelium-on crosslinking approach are excited to share their insights on this new option that they think will be safer for patients, facilitate faster healing, and could potentially stop progression of keratoconus sooner.

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EyeWorld Journal Club review: “Long-term outcomes of corneal crosslinking for keratoconus across pediatric, adolescent, and adult populations in a diverse U.S. population”

The John A. Moran Eye Center ophthalmology residents reviewed “Long-term outcomes of corneal crosslinking for keratoconus across pediatric, adolescent, and adult populations in a diverse U.S. population” from the September issue of the Journal of Cataract & Refractive Surgery.

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EyeWorld Weekly, September 18, 2026

➤ AMA classifies myopia as a disease ➤ Report marks shift in refractive surgery trends ➤ Patient dosing begins in Phase 2 trial for oral DME therapy ➤ ASCRS news and events ➤ EyeWorld article of the week

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EyeWorld Weekly, March 20, 2026

➤ FDA issues another response letter for dry eye NDA ➤ FDA denies approval for LHON NDA ➤ Commercial launch of epithelium-on crosslinking in the U.S. ➤ Company news ➤ ASCRS news and events

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EyeWorld Weekly, October 24, 2025

➤ FDA approves epithelium-on crosslinking treatment ➤ 12-month results from Phase 1/2 trial evaluating regenerative cell therapy for corneal endothelial disease ➤ Phase 3 data supports nonsteroidal treatment for uveitic macular edema ➤ FDA approves IDE for glaucoma device ➤ Company news ➤ ASCRS news and events

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EyeWorld Weekly April 11, 2025

➤ NDA submitted to the FDA for presbyopia drop ➤ FDA issues complete response letter to dry eye NDA ➤ FDA accepts BLA resubmission for bevacizumab to treat wet AMD ➤ One-month results in Phase 1/2 trial for treating Leber congenital amaurosis in a pediatric patient ➤ ASCRS news and events

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EyeWorld Weekly, February 28, 2025

➤ ASCRS EyeWorld Weekly: View the current issue ➤ Transepithelial crosslinking NDA submission accepted ➤ Fast Track designation granted to drop being investigated for night driving impairment due to visual disturbances ➤ First-in-human interventional study for gene therapy treating Leber congenital amaurosis 4 ➤ Positive outcomes observed for geographic atrophy drug ➤ Regenerative Medicine Advanced Therapy designation granted to stem cell therapy for dry AMD ➤ ASCRS news and events

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Crosslinking: then, now, and next up

With new techniques in (or having recently completed) Phase 3 clinical trials to potentially move crosslinking to the next stage in the U.S., EyeWorld spoke with specialists to look back at where keratoconus monitoring and treatment was, where it is now, and what could be coming.

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