EW Weekly, January 10, 2020

- Enrollment underway in VISTA-2 Phase 3 trial for dry eye
- Phase 2 results announced for NCX 4251 blepharitis treatment
- First patient treated in Phase 2 program for IVIEW-1201 for acute adenoviral conjunctivitis
- Enrollment completed in follow-on pilot study for punctate epitheliopathies
- Roclanda marketing application accepted in Europe
- Generic travoprost solution approved
- Merger agreement announced between Quantel Medical, Ellex
- Topline data announced from Phase 1 study for DME treatment
- First patient enrolled in Phase 3 GUARD trial for proliferative vitreoretinopathy
- A meta-analysis of randomized controlled trials with accelerated corneal collagen crosslinking (CXL) and standard corneal CXL found a comparable efficacy and safety profile after 1 year of follow-up, reported Hidenaga Kobashi, MD, and Kazuo Tsubota, MD. However, accelerated CXL had less impact on improving best spectacle-corrected visual acuity (BSCVA) compared with the Dresden protocol. Researchers identified six randomized controlled trials that evaluated the clinical outcomes of accelerated CXL and standard CXL for the treatment of progressive keratoconus. With standard CXL, there was a significantly better outcome in postop changes in BSCVA, but the differences may not be clinically significant, the researchers reported. There was a significantly better improvement of cylindrical refraction with accelerated CXL after 1 year of follow-up. The demarcation line depth at 1 month after standard CXL was deeper than that after accelerated CXL. No differences in maximum keratometry, central corneal thickness, uncorrected visual acuity, spherical equivalent refraction, corneal biomechanical properties, and corneal endothelial cell density were found. The research appears in Cornea.
- A better understanding of seasonal influences on postop infection might help with risk stratification and outcome improvisation, according to Soo Han Kim, MD, and fellow researchers. Their retrospective cohort study of endophthalmitis in South Korea found that incidences of post-cataract surgery endophthalmitis were higher during the hot and humid months. Researchers reviewed claims data from July 2014 to June 2017 and obtained monthly climate data. Incidences of endophthalmitis were assessed by month and by season. The association between postop endophthalmitis and climatic variables including mean temperature, relative humidity, precipitation, and hours of sunshine also were analyzed. Although there were fewer cataract surgeries performed in the warm summer months, incidences of endophthalmitis were higher in the summer months. Endophthalmitis tended to rise with increasing relative humidity and increasing precipitation. The study is published in the Journal of Cataract & Refractive Surgery.
This issue of EyeWorld Weekly was edited by Stacy Jablonski and Vanessa Caceres.
EyeWorld Weekly (ISSN 1089-0319), a digital publication of the American Society of Cataract and Refractive Surgery (ASCRS), is published every Friday, distributed by email, and posted live on Friday.
Medical Editors: Eric Donnenfeld, MD, Chief Medical Editor; Rosa Braga-Mele, MD, Cataract Editor; Clara Chan, MD, Cornea Editor; Nathan Radcliffe, MD, Glaucoma Editor; and Vance Thompson, MD, Refractive Editor
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