EW Weekly, November 8, 2019

- Expanded trial results from Aldeyra's allergen chamber trial for reproxalap released
- Phase 2 study topline results announced for netarsudil in Japan
- Study: Better opioid control possible after corneal surgery
- DEXYCU and YUTIQ added to Veterans Affairs federal supply schedule
- FDA accepts BLA for satralizumab for neuromyelitis optica spectrum disorder
- Submit your nomination for the inaugural ASCRS Educator Award
- A 10-year study found that age-related cataract was a predictor for poorer survival compared to those without cataract and may imply that cataract is a biomarker for aging and frailty, reported Zhuoting Zhu and coresearchers. Their research focused on a total of 1,405 participants age 50 or older in China who were examined at baseline in the Guangzhou Liwan Eye Study and then invited to attend a 10-year follow-up visit. Cataract cases were defined as having visible lens opacity confirmed with direct ophthalmoscope under pupil dilation or a previous history of cataract surgery. Researchers also tracked visual impairment, body mass index, and various demographics via a brief questionnaire. Among the participants examined at baseline, 68.1% had visible lens opacity or a history of cataract surgery. Over the subsequent 10 years, 22.8% died. The 10-year mortality rate was significantly higher in those who had cataract compared with those who did not (30.1% versus 7.14%). After adjustments, the presence of cataract predicted a nearly three-fold increase in mortality risk. The study is published in Acta Ophthalmologica.
- A systematic review and meta-analysis of extended depth-of-focus IOLs found that this type of IOL provided better intermediate and near visual acuity than monofocal IOLs but also increased the risk of contrast reduction and more frequent haloes, reported Jing Liu and coresearchers. They assessed nine studies with a total of 1,336 eyes. A subgroup analysis was done according to the IOL type used in the control group. Extended depth-of-focus IOLs produced better uncorrected intermediate visual acuity and uncorrected near visual acuity. There also was increased spectacle independence, lowered contrast sensitivity, and more frequent haloes. Extended depth-of-focus IOLs performed better than trifocal IOLs in contrast sensitivity. There were no adverse events reported in the studies. The review article is published in BMC Ophthalmology.
- When comparing the precision of bag-in-the-lens IOL power calculations among pediatric cataract patients of different ages, Lyubomyr M. Lytvynchuk, MD, PhD, and coresearchers found a larger prediction error in the youngest study group, which gradually became smaller with age and in eyes with axial lengths shorter than 20 mm. Their retrospective nonrandomized consecutive case series included 87 eyes of 56 pediatric patients. Patient age groups were 0 to 3 months (Group 1), 3 months to fewer than 12 months (Group 2), 12 months to 36 months (Group 3), and greater than 36 months to 17 years (Group 4). The bag-in-the-lens power was calculated with the SRK/T formula, and the prediction error was defined as the absolute difference between preop selected target and postop achieved refraction. The mean and median prediction errors overall were 1.79 D and 1.23 D, respectively. The mean prediction error in Group 1 was 3.43 D, 2.14 D in Group 2, 1.60 D in Group 3, and 1.33 D in Group 4. For eyes with axial lengths shorter than 20 mm, the mean prediction error was 2.67 D, compared with 1.44 D in eyes with an axial length of 20 mm or longer. Prediction error should be considered during bag-in-the-lens IOL power calculation in children, the researchers concluded. The study appears in the Journal of Cataract & Refractive Surgery.
This issue of EyeWorld Weekly was edited by Stacy Jablonski and Vanessa Caceres.
EyeWorld Weekly (ISSN 1089-0319), a digital publication of the American Society of Cataract and Refractive Surgery (ASCRS), is published every Friday, distributed by email, and posted live on Friday.
Medical Editors: Eric Donnenfeld, MD, Chief Medical Editor; Rosa Braga-Mele, MD, Cataract Editor; Clara Chan, MD, Cornea Editor; Nathan Radcliffe, MD, Glaucoma Editor; and Vance Thompson, MD, Refractive Editor
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