EW Weekly, September 20, 2019

- New Drug Application submitted for RVL-1201 to treat blepharoptosis
- Primary endpoint met in Phase 2b study of wet AMD treatment OPT-302
- Durability data announced from Phase 1b study of KSI-301 for wet AMD
- Data released from OPTIC Phase 1 trial’s first cohort for ADVM-022 for wet AMD
- Study: Methotrexate, mycophenolate mofetil perform similarly for noninfectious uveitis
- Submit your nomination for the inaugural ASCRS Educator Award
- Anterior chamber dimensions as determined by anterior chamber depth (ACD) and lower lens vault were significantly associated with diagnostic disagreement between anterior segment swept-source OCT (SS-OCT) and gonioscopy in angle closure assessment, reported Natalia Porporato, MD, and co-researchers. Their cross-sectional study included 2,027 phakic subjects age 50 or older. Gonioscopy and SS-OCT for the entire circumference of the angle were performed for each subject, and a two-quadrant closed gonioscopic definition was used. Angle closure was defined as iridotrabecular contact to the extent of 35% or higher, 50% or higher, and 75% or higher of the circumferential angle. Nearly 15% resulted in false positives when 50% or more of the angle circumference was closed using SS-OCT. Those eyes were significantly wider and deeper. A deeper ACD and lower lens vault were significantly associated with a false positive diagnosis; most of those cases had short (52.6%) or irregular (39%) iridotrabecular contact in SS-OCT images. The study is published in the British Journal of Ophthalmology.
- A similar ACD and aqueous depth (AQD) were significantly correlated with more endothelial cell loss in patients with iris-fixated phakic IOLs, according to Alaa Eldanasoury, MD, and coresearchers. Ninety eyes from 57 patients were retrospectively enrolled, and optimal cut-off values for ACD and AQD were assessed during a mean follow-up of 11.8 years. The mean ECD change from baseline was -53.5% in eyes with a preop ACD of 3.20 mm or greater, -26% in eyes with an ACD of 3.21-3.49 mm, and -5.2% in eyes with an ACD of 3.50 mm or greater (P<.001). There was no significant endothelial cell loss in eyes with an ACD of 3.50 mm or greater, but 84% of eyes with an ACD of 3.20 mm or less had significant endothelial cell loss. A minimum ACD of 3.35 mm or an AQD of 2.75 mm was recommended for better long-term endothelial safety. The research appears in the Journal of Refractive Surgery.
- A new assessment tool for simulation small-incision cataract surgery (SICS) had good face and content validity, reported William Dean, MD, and co-researchers. Their SICS Ophthalmic Simulated Surgical Competency Assessment Rubric (OSSCAR) was developed by an international group of experienced ophthalmologists. Both novice and competent surgeons from four countries were recorded performing surgery. Masked assessments were performed by four expert surgeons. When a panel of 12 international experts were asked if the OSSCAR represented surgical techniques and skills upon which trainees should be assessed, all respondents agreed or strongly agreed. Face validity was rated 4.60 out of 5.0. Final content validity was rated as 4.5. The new assessment tool could play a role in ophthalmic surgical education, the researchers concluded. The study is published in the Journal of Cataract & Refractive Surgery.
- The TECNIS Synergy IOL (Johnson & Johnson Vision) is now available for cataract surgery patients in Europe, Australia, and New Zealand, according to a company press release.
Product news
This issue of EyeWorld Weekly was edited by Stacy Jablonski and Vanessa Caceres.
EyeWorld Weekly (ISSN 1089-0319), a digital publication of the American Society of Cataract and Refractive Surgery (ASCRS), is published every Friday, distributed by email, and posted live on Friday.
Medical Editors: Eric Donnenfeld, MD, Chief Medical Editor; Rosa Braga-Mele, MD, Cataract Editor; Clara Chan, MD, Cornea Editor; Nathan Radcliffe, MD, Glaucoma Editor; and Vance Thompson, MD, Refractive Editor
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