EyeWorld Weekly Update, January 27, 2017
Dextenza NDA resubmitted
GCA drug candidate granted priority review
Nicox finalizing NCX 470 study details
Ocriplasmin, robotics used to dissolve blot clots in RVO
- Higher corneal hysteresis (CH) in glaucoma-like optic discs (GLD) and ocular hypertension (OHT) compared to glaucoma suggests increased viscoelasticity of ocular tissues may have a protective role against glaucoma, according to Melissa Murphy and colleagues. They compared CH among patients with glaucoma, OHT, and GLD (the latter of which was defined as a cup to disc ratio greater than or equal to 0.6 with normal IOP and visual fields) in 123 eyes (123 patients). Mean CH was significantly higher for GLD compared to glaucoma (mean difference 1.83, p<0.001), and significantly higher for OHT compared to glaucoma (mean difference 2.35, p<0.001). Mean CH was slightly lower in patients with GLD than those with OHT, but this difference was not statistically significant. A similar pattern was seen when the analysis was repeated for corneal resistance factor and central corneal thickness. The study is published in BMC Ophthalmology.
- Tear function is significantly disturbed in idiopathic dacryoadenitis, according to a study. K. Xue and colleagues enrolled 16 subjects and divided them into three groups: patients with idiopathic dacryoadenitis with affected sites (group 1), with contralateral sites (group 2), and healthy participants (group 3). Tear meniscus height and tear meniscus area were the lowest in patients with affected sites (group 1) among the three groups (p<0.05). Breakup time was the shortest in group 1 (p<0.05). In group 1, breakup time, fluorescein staining score, and histopathological phases were significantly correlated with tear meniscus height and tear meniscus area (p<0.05). The study is published in Ophthalmic Plastic and Reconstructive Surgery.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids do not create significant difference in the conformational changes of cataract wounds when administered postoperatively, according to Eun Young Choi, MD, and colleagues. In their prospective, randomized, comparative study, eyes undergoing cataract surgery in South Korea were randomly given an NSAID (bromfenac 0.1%; n=29) or a steroid (prednisolone acetate 1.0%; n=30). Using anterior segment optical coherence tomography (AS-OCT), structural changes of clear corneal incisions were examined 1 day and 1, 3.5, and 23 weeks postoperatively. During the 6-month follow-up, the overall changes in wound instability were not significantly different between groups, although epithelial detachment or a larger defect was more frequent in the bromfenac group between 1 week and 3.5 weeks postoperatively. The surgically induced astigmatism at 1 week was positively correlated with wound instability, and wound instability at 1 day was positively correlated with cataract grading in both groups. The study is published in the Journal of Cataract & Refractive Surgery.
NEW PRODUCT BRIEFS
- Nidek (Gamagori, Japan) launched the OPD-Scan III VS, an aberrometer providing optimal and facilitated eyeglass prescription with detailed measurement data. This device mainly measures corneal shape (topographer) and refractive error (refractometer). It clarifies causes of vision difficulties through wavefront analysis of information measured over a wide area.
EYEWORLD WEEK Online is edited by Stacy Majewicz and Michelle Dalton.
EyeWorld Week Online (ISSN 1089-0319), a digital publication of the American Society of Cataract and Refractive Surgery and the American Society of Ophthalmic Administrators, is published every Friday, distributed by email, and posted live on Friday.
Medical Editors: David F. Chang, MD, chief medical editor; Bonnie An Henderson, MD, cataract editor; Clara C. Chan, MD, cornea editor; Reay H. Brown, MD, glaucoma editor; Kerry D. Solomon, MD, refractive editor; and John A. Vukich, MD, international editorFor sponsorship opportunities or membership information, contact:
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