June-July 2020

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Distinct differences in anterior chamber configuration and peripheral aberrations in negative dysphotopsia


Luc van Vught, BSc, Gregorius Luyten, MD, Jan-Willem Beenakker, MSc

Cataract Refract Surg. 2020;46(7). Article in press.

Purpose: Provide insight in the anatomical characteristics associated with negative dysphotopsia using quantitative clinical data.
Setting: Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
Design: Case-control study.
Methods: Anterior chamber tomography and peripheral aberrometry were measured in twenty-seven pseudophakic patients with negative dysphotopsia (ND) and thirty pseudophakic controls. Based on these measurements, the total corneal power, anterior chamber depth, pupil location and diameter, iris tilt and peripheral ocular wavefront up to 30 degrees eccentricity were compared between both groups. Additionally, ray tracing simulations using pseudophakic eye models were performed to establish a connection between these clinical measurements and current hypotheses on the etiology of ND.
Results: Patients with ND have a smaller (p=0.03/p=<0.01) and more decentered (p<0.01) pupil than pseudophakic controls. Additionally, an increased temporal tilted iris (p<0.01) and an asymmetric peripheral aberration profile were observed in patients with ND, of which the latter was also apparent in a number of ray tracing models. The combination of these in vivo results and ray tracing simulations indicates that patients with ND have a temporal rotated eye, which confirms the hypothesized relation between ND and an increased angle kappa.
Conclusions: Patients with negative dysphotopsia have a smaller pupil and an increased angle kappa, which make them more susceptible to experience a shadow in the temporal visual field.

Distinct differences in anterior chamber configuration and peripheral aberrations in negative dysphotopsia Distinct differences in anterior chamber configuration and peripheral aberrations in negative dysphotopsia
Ophthalmology News - EyeWorld Magazine
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2020-06-22T11:34:54Z
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