October 2019

ASCRS NEWS

Cystoid macular edema following prostaglandin analogue use after uncomplicated cataract surgery in glaucoma patients:
A randomized clinical trial


Ghasem Fakhraie, MD, Masoud Mirghorbani, MD, L. Jay Katz, MD, Amirhossein Mollazadeh, MD, Zakieh Vahedian, MD, Reza Zarei, MD, Yadollah Eslami, MD, Masoud Mohammadi, MD, Nikoo Hamzeh, MD, Ahmad Masoomi, MD

J Cataract Refract Surg. 2019;45(10):1436–1445.

• Purpose: To evaluate the effect of postoperative latanoprost administration on central macular thickness (CMT) after uncomplicated cataract surgery in glaucoma patients.
• Setting: Farabi Eye Hospital (tertiary referral center), Tehran, Iran
• Design: Randomized clinical trial
• Methods: Glaucoma patients treated with latanoprost who needed cataract surgery and had no other risk factor for development of pseudophakic macular edema (PME) were randomly allocated into two groups, continuation of latanoprost in one group and discontinuation (DC) of the drop in the other group, following uneventful cataract surgery. The trial was single-masked. Patients underwent complete ocular examination and measurement of central macular thickness (CMT) by optical coherence tomography (OCT) at baseline. OCT was repeated at postoperative months 1 and 3. Main outcome parameter was defined as the change in CMT between preoperative measurement and postoperative 1 and 3 months.
• Results: 156 eyes finished the trial (latanoprost: 76 and DC: 80). There were no differences in demographic and baseline characteristics including preoperative CMT between the two groups. Transient mean increase in CMT developed in the latanoprost group at month 1 (12±49 µm; p=0.03), but the mean CMT was unchanged at month 3 compared to the baseline (6±55 µm; p=0.27). The difference in mean CMT change from baseline between the two groups was –3.1 (95% CI: –18.4 to 12.0; p=0.68) after 1 month and –10.5 (95% CI: –26.6 to 5.5; p=0.19) after 3 months; both were insignificant.
• Conclusions: We did not find any measurable effect on macular thickness following latanoprost administration after cataract surgery.

Cystoid macular edema following prostaglandin analogue use after uncomplicated cataract surgery in glaucoma patients: A randomized clinical trial Cystoid macular edema following prostaglandin analogue use after uncomplicated cataract surgery in glaucoma
Ophthalmology News - EyeWorld Magazine
283 110
283 110
,
2019-09-30T14:17:10Z
True, 10