June 2019

ASCRS NEWS

Eyeworld journal club
Comparative analysis of intravitreal triamcinolone acetonide/moxifloxacin versus standard peri-operative eye drops in cataract surgery


by Saman Nassiri, MD, Frank Hwang, MD, Jason Kim, MD, Bronson LeClair, MD, Eden Yoon, MD, Michael Pham, DO, Michael Rauser, MD

J Cataract Refract Surg. 2019;45(6):760–765.

• Purpose: To compare the effectiveness of intravitreal injection of triamcinolone acetonide/moxifloxacin (Tri-Moxi) to standard eye drop regimen in controlling postoperative inflammation, corneal edema and the rate of high IOP among cataract patients.
• Setting: Loma Linda University Eye Institute, Loma Linda, California.
• Design: Retrospective longitudinal comparative study.
• Methods: We reviewed the electronic medical records of patients who underwent cataract surgery using triamcinolone acetonide/moxifloxacin injection along with postoperative NSAID drop (Group 1). We compared this group to patients who received standard eye drop (Group 2) in terms of intraocular inflammation and corneal edema severity, and the rate of high IOP, postoperatively.

• Results: A total of 1195 consecutive eyes (Group 1: 681, Group 2: 514) of 919 patients were included in the study. Postoperative anterior chamber cell reaction severity decreased by 34.0% and 35.7% 1 week and 1 month after surgery following triamcinolone acetonide/moxifloxacin injection compared to standard eye drop therapy (P=.001 and P=.02, respectively). Group 1 was associated with increased severity of corneal edema (OR: 1.48; P=.001) on postoperative day 1, with no statistically significant difference at week 1 and month 1 (P=.25 and .48, respectively). There was no statistically significant difference in the rate of high IOP between groups at different time points postoperatively.
Conclusions: Triamcinolone acetonide/moxifloxacin injection is an effective method to control intraocular inflammation following cataract surgery. It is a promising substitute for standard eye drop therapy, especially in patients who have poor compliance with eye drop usage.

Comparative analysis of intravitreal triamcinolone acetonide/moxifloxacin versus standard peri-operative eye drops in cataract surgery Comparative analysis of intravitreal triamcinolone acetonide/moxifloxacin versus standard peri-operative eye
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2019-06-04T07:26:51Z
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