January 2008




VA & contrast improved in cataract patients


According to a recent study, published in the European Journal of Ophthalmology, patients with AMD benefit from cataract surgery, both in terms of visual acuity (VA) and contrast sensitivity.

D. Zaliuniene, department of Ophthalmology, Kaunas University of Medicine, Kaunas, Lithuania, and colleagues, set out to evaluate whether patients with early or intermediate forms of age-related macular degeneration (AMD) benefit from cataract surgery in terms of visual acuity and contrast sensitivity, and to establish the levels of high sensitivity C-reactive protein (hsCRP) as a systemic marker of inflammation before and after cataract surgery in patients with AMD. The study authors wrote that three groups of patients (n=132) were studied at baseline with a 8-12 week follow-up. Group 1 was a study group of patients with AMD who underwent cataract surgery (n=47), group 2 was a control group of patients without ocular comorbidities who underwent cataract surgery (n=36), and group 3 was a second control group with AMD and no surgery (n=49). Letter charts were used to obtain visual acuity (VA), which was expressed as decimal notations +/– SD, the authors wrote. The Ginsburg Box, VSCR-CST-6500 was used to measure contrast sensitivity and the hsCRP was measured by means of particle enhanced immunonephelometry on a BN Systems, the study said.

The researchers determined postoperative improvement in VA (0.23+/–0.17 vs 0.64+/–0.25 and 0.23+/–0.18 vs 0.83+/–0.17, respectively, P<0.0001) in both groups of the operated patients and as well as improvement in contrast sensitivity (at different spatial frequencies, from 1.5 to 18 cycles/degree, P<0.05). The study authors wrote that at baseline, the hsCRP level in Group 1 patients was higher than the level in controls (2.67+/–2.36 vs 1.67+/–1.36, P<0.01, or 1.12+/–0.99 mg/L, P<0.0001, respectively). The researchers also found that after 8-12 weeks, the hsCRB level only in Group 1 significantly increased (2.67+/–2.36 vs 3.74+/–3.54 mg/L, P<0.05), whereas in the controls it did not change. The authors concluded that the level of hsCRP is significantly higher in patients with AMD and moderate cataract than in patients with one of these eye disorders. The hsCRP only increases after cataract surgery in patients with AMD, the authors wrote.

Source: EyeWorld News Services

VA & contrast improved in cataract patients VA & contrast improved in cataract patients
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