November 2007

 

OPHTHALMOLOGY NEWS

 

Study finds clues for autoimmune involvement in glaucoma


 
 

 

A recent study, published recently Molecular Vision, suggests that the analysis of intraocular antibodies could provide further hints for autoimmune involvement in glaucoma.

In the study, Stephanie C. Joachim, Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany, and colleagues wrote, “There has been growing body of evidence indicating an immunological component in the pathogenesis of glaucoma. Several studies found specific antibodies in sera of glaucoma patients.”

The team recently detected antibody profiles in aqueous humor of patients with normal tension glaucoma that showed significant differences when compared to control subjects, the study said. The researchers therefore sought to compare the IgG antibody patterns against retinal antigens in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation glaucoma, and control subjects then to identify some of the important biomarkers of this study.

The researchers analyzed the aqueous humor of 44 patients: 15 patients with primary open angle glaucoma (POAG), 14 patients with pseudoexfoliation glaucoma (PEX), and 15 control subjects (CO), the study said. The researchers tested the aqueous against western blots of bovine retinal antigens. Results showed all patients had complex patterns of IgG antibodies against retinal antigens. The discriminant analysis revealed a statistically significant difference between the antibody profiles of the POAG and the CO group (P=0.00018). The study authors also found a statistically significant difference between the antibody profiles of the PEX and the CO group (P=0.0013). Not only were up-regulations in the glaucoma groups observed, compared to controls, but also down-regulations. No significant difference was found between the antibody patterns of the POAG and PEX group, the study said. We could show significant differences between the IgG antibody profiles of the glaucoma groups (PEX and POAG) and controls.

Reported by: EyeWorld News Service

Study finds clues for autoimmune involvement in glaucoma Study finds clues for autoimmune involvement in glaucoma
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