April 2008

 

CATARACT/ IOL

 

Study compares IOL designs for PCO rates


   

Modern foldable intraocular lenses (IOLs) have a low incidence of posterior capsular opacification (PCO) after three years, according to a recent study.

In addition, there is less PCO for sharp optic edge designs independent of IOL material, said Thomas Kohnen, M.D., Johann Wolfgang Goethe-University, Frankfurt, Germany, in the March issue of Ophthalmology.

In an open-label, prospective, randomized, multicenter clinical trial, 288 patients underwent bilateral surgery for senile cataracts. Each patient had a highly refractive index silicone IOL with a sharp optic edge (silicone-sharp) and a high-refractive index silicone IOL with a round optic edge (silicone-round, 108 patients) or an acrylic IOL with a sharp optic edge (acrylic, 139 patients).

All patients received standard phacoemulsification with IOL implantation in the bag in both eyes from the same surgeon. A morphological evaluation of PCO was performed by the Evaluation of the Posterior Capsule Opacification (EPCO) system 1 to 2 weeks and 11 to 14 and 35 to 37 months after surgery. The blinded digital pictures were evaluated by an independent investigator. Posterior capsular opacification was statistically evaluated by paired comparisons of 3-year cumulative incidences of neodymium:yttrium-aluminum-garnet (Nd:YAG) laser treatment and EPCO scores.

The three-year cumulative incidences of Nd:YAG laser capsulotomy were 2.1% (silicone-sharp), compared with 2.1% (acrylic) (risk difference, 0%; 90% confidence interval, –3.4% to 3.4%), and 5.7% (silicone-sharp), compared with 17.0% (silicone-round) (risk difference, –11.4%; 90% confidence interval, –18.1% to –4.7%). In patients without Nd:YAG laser treatment, medians of the total area EPCO score were 0.0005 (silicone-sharp) versus 0.0440 (acrylic) and 0 (silicone-sharp) versus 0.0700 (silicone-round) at three years.

Functional results, safety, and handling did not significantly differ for the three lenses.

Reported by: EyeWorld News Services

Study compares IOL designs for PCO rates Study compares IOL designs for PCO rates
Ophthalmology News - EyeWorld Magazine
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2016-07-26T13:36:19Z
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