May 2010

 

OPHTHALMOLOGY NEWS

 

Not all cases of prethreshold retinopathy of prematurity benefit from early ablation treatment


   

A recent study has found that only children with certain characteristics of prethreshold retinopathy of prematurity (ROP) get a long-term benefit from early ablation treatment, according MedPage Today reported.

William V. Good, M.D., Smith-Kettlewell Eye Research Institute, Calif., and colleagues found that overall, treating babies at high risk of progression to ROP did not reduce their risk of poor visual acuity at age 6 years compared with conventional cautious observation with treatment only after children reached the threshold for disease (24.6% versus 29.0%, P=0.15).

However, the researchers reported that early treatment of those with “type 1 eyes” marked by dilation and tortuosity of retinal blood vessels in at least two quadrants of zone I or II or stage III disease in zone I did reduce their risk of 20/200 or worse visual acuity at age 6 (25.1% versus 32.8%; P=0.02).

Published online in the Archives of Ophthalmology, the study showed no visual acuity benefit from early treatment emerged at age 6 for those with all other clinical characteristics—referred to as “type 2”—compared with conventional management (23.6% versus 19.4%, P=0.37).

“These results are particularly important considering that 52% of type 2 high-risk prethreshold eyes underwent regression of retinopathy of prematurity without requiring treatment,” the researchers wrote.

In addition, they noted that given the possible risks for cataract and increased systemic risk for apnea and bradycardia, exercising restraint and clinical judgment when deciding whether to operate on type 2 eyes unless they show signs of further progression, would be wise.

The American Academy of Ophthalmology issued a statement that said the findings affirmed the efficacy and long-term benefit of current retinopathy of prematurity diagnosis and treatment practices.

Source: http://www.medpagetoday.com/Ophthalmology/GeneralOphthalmology/19512

Reported by EyeWorld News Services

Not all cases of prethreshold retinopathy of prematurity benefit from early ablation treatment Not all cases of prethreshold retinopathy of prematurity benefit from early ablation treatment
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