February 2007

 

CATARACT/ IOL

 

Candidal transmission … increases with elevated temperatures?


 

 

 

A recent study, published in the December issue of the American Journal of Ophthalmology, suggests that increased external temperatures at the time of corneal donation are possibly linked with an increased relative risk of candidal transmission by keratoplasty.

Kirk R. Wilhelmus M.D., Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas and corresponding author, Sohela S. Hassan, Ph.D., conducted a study to investigate ecological effects on eye banking.

Using a retrospective case-control study design, the researchers examined the climatic conditions, which had been reported to a national surveillance registry, at corneal donation for microbial categories of postkeratoplasty endophthalmitis.

The study authors tabulated local weather information on the date of donor corneal procurement for reported cases of endophthalmitis after penetrating keratoplasty. They then compared candidal endophthalmitis with postsurgical endophthalmitis that yielded bacteria or no microorganisms or that were not cultured, the study authors wrote.

Results showed that candidal endophthalmitis (after corneal transplantation) occurred significantly (P < 0.001) more often, compared with other postkeratoplasty endophthalmitis when outdoor afternoon temperatures exceeded 75° F at the source eye bank compared to cooler days.

The researchers concluded that higher exterior temperatures at corneal donation time may be associated with an increased relative risk of candidal transmission by keratoplasty but highlighted that a chain of causation linking the donor’s environment to the recipient’s infection needs further study.

Source: Hassan S, Wilhelmus K. Am. J. of Ophthal. 2006; 142(6):1062-64.

Reported by: EyeWorld News Service

Candidal transmission … increases with elevated temperatures? Candidal transmission … increases with elevated temperatures?
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