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EW Supplement: Clinical Study Update: Surgical Therapeutics



     

Aqueous Penetration and Biological Activity of Moxifloxacin 0.5% and Gatifloxacin 0.3% Ophthalmic Solutions in Cataract Surgery Patients


 
 
 

* Trademark is the property of its owner.

 

This figure shows the median minimum bactericidal concentration (MBC) for gatifloxacin (ZYMAR*) and moxifloxacin
(VIGAMOX® solution, Alcon, Fort Worth, Texas) against a variety of gram-positive and gram-negative organisms compared to the mean aqueous concentration levels achieved by the two fluoroquinolones in a study completed by researchers at the Wilmer Eye Institute, Johns Hopkins Bayview Medical Center, Baltimore.1

A lower concentration of moxifloxacin is needed to kill the relevant bacteria when compared to gatifloxacin, and moxifloxacin achieves higher drug levels than does gatifloxacin in the aqueous humor. These data are clinically significant as they are representative of real-life cataract surgery with human tissue concentrations for anti-infectives and potential infectious pathogens.





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